Michelangelo Buonarroti, arguably the greatest of the Italian Renaissance artists, is born in the small village of Caprese on March 6, 1475. The son of a government administrator, he grew up in Florence, a center of the early Renaissance movement, and became an artist’s apprentice at age 13. Demonstrating obvious talent, he was taken under the wing of Lorenzo de’ Medici, the ruler of the Florentine republic and a great patron of the arts. He would go on to master painting, sculpture and even architecture, becoming best known for powerful sculptures like David and for his ceiling frescoes at the Vatican's Sistine Chapel.

On March 6, 1820, President James Monroe signs the Missouri Compromise, also known as the Compromise Bill of 1820, into law. The bill attempted to equalize the number of slave-holding states and free states in the country, allowing Missouri into the Union as a slave state while Maine joined as a free state. Additionally, portions of the Louisiana Purchase territory north of the 36-degrees-30-minutes latitude line were prohibited from engaging in slavery by the bill.

The German company Bayer patents aspirin on March 6, 1899. Now the most common drug in household medicine cabinets, acetylsalicylic acid was originally made from a chemical found in the bark of willow trees. In its primitive form, the active ingredient, salicin, was used for centuries in folk medicine, beginning in ancient Greece when Hippocrates used it to relieve pain and fever. Known to doctors since the mid-19th century, it was used sparingly due to its unpleasant taste and tendency to damage the stomach.

On March 6, 1902, the Madrid Foot Ball Club is founded by a group of fans in Madrid, Spain. Later known as Real Madrid, the club would become the most successful European football (soccer) franchise of the 20th century.

The trial of Ethel and Julius Rosenberg begins in New York Southern District federal court. Judge Irving R. Kaufman presides over the espionage prosecution of the couple accused of selling nuclear secrets to the Russians (treason could not be charged because the United States was not at war with the Soviet Union). The Rosenbergs, and co-defendant Morton Sobell, were defended by the father and son team of Emanuel and Alexander Bloch. The prosecution includes Roy Cohn, best known for his association with Senator Joseph McCarthy.

Journalist Helen Thomas is named United Press International's White House Bureau Chief on March 6, 1974. At a press conference that day, President Nixon personally congratulates her on becoming the first woman to serve in the distinguished role. The moment marks the beginning of a boundary-breaking career, in which Thomas becomes a fixture in the White House briefing room.

On March 6, 1981, CBS Evening News anchor Walter Cronkite signs off with his trademark valediction, "And that's the way it is," for the final time. Over the previous 19 years, Cronkite had established himself not only as the nation's leading newsman but as "the most trusted man in America," a steady presence during two decades of social and political upheaval.

Helmut Kohl, the interim chancellor of West Germany since the fall of Helmut Schmidt’s Social Democrat government in 1982, is elected German chancellor as his Christian Democratic Union (CDU) party is voted back into power.

A British ferry leaving Zeebrugge, Belgium, capsizes, drowning 188 people, on March 6, 1987. Shockingly poor safety procedures led directly to this deadly disaster. Lord Justice Barry Sheen, an investigator of the accident, later said of it, from top to bottom, the body corporate was affected with the disease of sloppiness.

After a string of adverse legal decisions, Napster, Inc. begins its death spiral on March 6, 2001, when it starts to comply with a Federal court order to block the transfer of copyrighted material over its peer-to-peer music-sharing network.