Future President Thomas Jefferson is elected to the second Continental Congress on March 27, 1775. Jefferson, a Virginia delegate, quickly established himself in the Continental Congress with the publication of his paper titled A Summary View of the Rights of British America. Throughout the next year, Jefferson published several more papers, most notably Drafts and Notes on the Virginia Constitution.

On March 27, 1865, President Abraham Lincoln meets with Union generals Ulysses S. Grant and William T. Sherman at City Point, Virginia, to plot the last stages of the Civil War.

On March 27, 1929, President Herbert Hoover has a phone installed at his desk in the Oval Office of the White House. It took a while to get the line to Hoover’s desk working correctly and the president complained to aides when his son was unable to get through on the Oval Office phone from an outside line. Previously, Hoover had used a phone located in the foyer just outside the office. Telephones and a telephone switchboard had been in use at the White House since 1878, when President Rutherford B. Hayes had the first one installed, but no phone had ever been installed at the president’s desk until Hoover’s administration.

The University of Oregon defeats The Ohio State University 46–33 on March 27, 1939 to win the first-ever NCAA men’s basketball tournament. "March Madness," as the tournament became known, has grown exponentially in size and popularity since 1939. By 2005, college basketball had become the most popular sporting event among gamblers, after the Super Bowl. The majority of that betting takes place at tournament time, when Las Vegas, the internet and office pools around the country see action from sports enthusiasts and once-a-year gamblers alike.

On March 27, 1958, Soviet First Secretary Nikita Khrushchev replaces Nicolay Bulganin as Soviet premier, becoming the first leader since Joseph Stalin to simultaneously hold the USSR’s two top offices.

On March 27, 1977, two 747 jumbo jets crash into each other on the runway at an airport in the Canary Islands, killing 583 passengers and crew members.

On March 27, 1979, one of pop music's most famous love triangles shifts when British Blues guitarist Eric Clapton finally marries his muse, former model Pattie Boyd. He had been pursuing her since she was married to one of his best friends, Beatle George Harrison.

On March 27, 1998, the Food and Drug Administration (FDA) approves use of the drug Viagra, an oral medication that treats impotence.