Upon landing in Egypt, Roman general and politician Pompey is murdered on the orders of King Ptolemy of Egypt.

On September 28, 1542, the Spanish explorer Juan Rodriguez Cabrillo arrives in San Diego Bay while searching for the Strait of Anian, a mythical all-water route across North America.

On September 28, 1901, Ed Sullivan, who will become the host of the long-running TV variety program "The Ed Sullivan Show_,_" is born in New York City. During the peak of its popularity in the 1950s and 1960s, Sullivan’s program showcased a wide range of entertainers, including Elvis Presley, the Beatles, Rudolf Nureyev, Jerry Lewis and Bob Hope.

On September 28, 1918, in an incident that would go down in the lore of World War I history—although the details of the event are still unclear—Private Henry Tandey, a British soldier serving near the French village of Marcoing, reportedly encounters a wounded German soldier and declines to shoot him, sparing the life of 29-year-old Lance Corporal Adolf Hitler.

On September 28, 1920, a Chicago grand jury indicts eight members of the Chicago White Sox on charges of fixing the 1919 World Series. White Sox owner Charles Comiskey immediately suspends Chick Gandil, Buck Weaver, Happy Felsch, Swede Risberg, Fred McMullin, Eddie Cicotte, Lefty Williams and "Shoeless" Joe Jackson, who are notorious for their involvement in the "Black Sox Scandal."

On September 28, 1965, six years after he led the Cuban Revolution and four years after the failed U.S.-backed Bay of Pigs Invasion, Fidel Castro announces that any Cuban who wished to leave the island was free to do so. With Cuban forces no longer blocking civilians from leaving, a massive wave of emigration ensued, bringing hundreds of thousands of Cuban immigrants to Florida.

Roch Theriault fatally wounds Solange Boilard in Ontario, Canada. Theriault, the leader of the most bizarre and violent cult in Canadian history, often physically abused his followers. Obsessed with anatomy and medicine, Theriault performed crude intestinal surgery on Boislard by slicing open her abdomen and ripping out a piece of intestine with his bare hands. He then ordered another follower to stitch up the wound with a needle and thread. When she died the next day in agonizing pain, he sawed off the top of her head, and then sexually assaulted her. Before burying the woman, he removed a rib, which he wore around his neck.

On September 28, 2018, the cargo ship Venta Maersk docks in St. Petersburg, Russia, more than a month after departing from Vladivostok on the other side of the country. The successful traversal of the Russian Arctic was a landmark moment for the international shipping industry, as well as a sobering reminder of the extent to which the Earth's ice caps had melted.