On December 4, 2009, 22-year-old American exchange student Amanda Knox is convicted of murdering her British roommate, Meredith Kercher, in 2007 in Perugia, Italy. Knox received a 26-year prison sentence, while her 25-year-old Italian ex-boyfriend, Raffaelle Sollecito, who also was convicted in the slaying, was sentenced to 25 years behind bars. The sensational, high-profile case raised questions in the United States about whether Knox, who always maintained her innocence, received a fair trial. Then, in October 2011, in a decision that made international headlines, an Italian court reversed the murder convictions of both Knox and Sollecito and they were freed from prison.

On November 2, 2007, 21-year-old Kercher of Coulsdon, England, was found fatally stabbed in the bedroom of the home she shared with Knox and two other women in Perugia, the capital city of the Umbria region in central Italy. Investigators said the British exchange student had been slain the previous night. After questioning by police, Knox, a Seattle native and University of Washington student doing her junior year abroad in Italy, was arrested. She denied any wrongdoing, saying she was at computer science student Sollecito’s house the night the killing occurred. Police claimed Knox later gave them conflicting statements about her whereabouts at the time of the crime, and said she also accused her boss at a bar where she worked, who turned out to have a solid alibi, of Kercher’s murder. The American student, who was first questioned without an attorney or professional interpreter, said police coerced her into making the accusation as well as other incriminating statements. (The false accusation would later result in an extra year tacked on to Knox’s prison sentence.)

During the nearly yearlong trial that followed in 2009, Italian prosecutors charged that Knox, along with Sollecito and a third person, Rudy Guede, an Ivory Coast native, had viciously attacked Kercher in a sex game gone wrong. (Guede was convicted for his role in Kercher’s death in a separate, fast-track trial in 2008. He was sentenced to 30 years in prison, which was reduced to 16 years on appeal.) The prosecution’s main evidence against Knox included tiny traces of her DNA and that of Kercher’s on a knife discovered at Sollecito’s home. Traces of Knox’s DNA were also found on a bra clasp belonging to Kercher. Knox’s attorneys argued the bra clasp was found over a month after the murder at a contaminated crime scene, and that the knife blade couldn’t have made the wounds on the victim.

The case received extensive media coverage in the U.S. and Europe, where the attractive Knox was dubbed “Angel Face” and “Foxy Knoxy” by the tabloids. In the Italian and British press, Knox was painted as a promiscuous party girl. However, in America, she was often portrayed in the media as an innocent abroad, a young woman who had worked several jobs to earn money to study in Perugia, where she had been railroaded by an overzealous prosecutor.

Knox and Sollecito appealed their convictions, and at their subsequent trial court-appointed experts testified the original DNA evidence was unreliable and did not definitively link the young American and her former boyfriend to the crime. On October 3, 2011, a court in Perugia acquitted the two defendants of murder. The 24-year-old Knox, who been jailed in Italy since her 2007 arrest, flew home to the U.S. the following day.

In March 2013, in a new twist in the case, Italy’s highest court overturned the acquittals of Knox and Sollecito and ordered that they be retried. In January 2014, the two were re-convicted in Kercher’s death. Knox, who remained in America during the trial, was sentenced to 28 1/2 years years behind bars, while her former boyfriend received a 25-year prison sentence. Lawyers for the two appealed the convictions. Both were fully exonerated in 2015.