Citing political differences with President Andrew Jackson and a desire to fill a vacant Senate seat in South Carolina, John C. Calhoun becomes the first vice president in U.S. history to resign the office.
Born near Abbeville, South Carolina, in 1782, Calhoun was an advocate of states’ rights and a defender of the agrarian South against the industrial North. Calhoun served as secretary of war under President James Monroe and in 1824 ran for the presidency. However, bitter partisan attacks from other contenders forced him out of the race, and he had to settle for the vice presidency under President John Quincy Adams.