Legend has it that on the night of December 2, 1777, Philadelphia housewife and midwife Lydia Darragh single-handedly saves the lives of General George Washington and his Continental Army when she overhears the British planning a surprise attack on Washington’s army for the following day.

During his annual address to Congress, President James Monroe proclaims a new U.S. foreign policy initiative that becomes known as the “Monroe Doctrine.” Primarily the work of Secretary of State John Quincy Adams, the Monroe Doctrine forbade European interference in the American hemisphere but also asserted U.S. neutrality in regard to future European conflicts.

Enrico Fermi, the Italian-born Nobel Prize-winning physicist, directs and controls the first nuclear chain reaction in his laboratory beneath the bleachers of Stagg Field at the University of Chicago, ushering in the nuclear age. Upon successful completion of the experiment, a coded message was transmitted to President Roosevelt: “The Italian navigator has landed in the new world.”

The U.S. Senate votes 65 to 22 to condemn Senator Joseph R. McCarthy for conduct unbecoming of a senator. The condemnation, which was equivalent to a censure, related to McCarthy’s controversial investigation of suspected communists in the U.S. government, military and civilian society.

On December 2, 1970, a new federal agency opens its doors. Created in response to the dawning realization that human activity can have major effects on the planet, the Environmental Protection Agency heralded a new age of government action on behalf of the environment.

On December 2, 1972, the Temptations earn the last of their four chart-topping hits when “Papa Was A Rollin’ Stone” reaches #1 on the Billboard Hot 100.

Opening testimony takes place in the highly publicized rape trial of William Kennedy Smith, a nephew of President John F. Kennedy and son of Jean Kennedy Smith, the president’s sister and a former ambassador to Ireland. Smith, then a 30-year-old medical student at Georgetown University, was accused of sexually assaulting a 29-year-old Florida woman in the early hours of March 30, 1991, at the Kennedy family’s Palm Beach compound.

On December 2, 1999, in the journal Nature, scientists announce that they have sequenced the DNA of a human chromosome for the first time. The genetic sequence of chromosome 22 is one of the first major findings of the Human Genome Project, an international scientific effort to decode the instructions for life hidden in our cells.

On December 2, 2006, four students at the University of California, Berkeley, inhabit the treetops of an oak grove on campus to protest the university’s plans to demolish over an acre of the forest to build a new athletic center, kicking off an epic 21-month standoff. It was one of the longest tree sit-ins in history.