On April 22, 1876, the Boston Red Caps beat the Philadelphia Athletics, 6-5, in the first official National League baseball game. The game, which lasts a little more than two hours, is played in "favorable" weather before 3,000 fans at the Athletics' grounds at 25th and Jefferson streets. "Great interest was manifested in the result," the Philadelphia Inquirer reports, "as it really was the first game of importance played this season."

At precisely high noon, thousands of would-be settlers make a mad dash into the newly opened Oklahoma Territory to claim cheap land.

On April 22, 1915, German forces shock Allied soldiers along the western front by firing more than 150 tons of lethal chlorine gas against two French colonial divisions at Ypres, Belgium. This was the first major gas attack by the Germans, and it devastated the Allied line.

On April 22, 1945, Adolf Hitler, learning from one of his generals that no German defense was offered to the Russian assault at Eberswalde, admits to all in his underground bunker that the war is lost and that suicide is his only recourse.

On April 22, 1957, John Irvin Kennedy becomes the first African American player on the Philadelphia Phillies, fully integrating the National League 10 years after Jackie Robinson broke Major League Baseball's color barrier. In the eighth inning of a 5-1 loss to the Brooklyn Dodgers at Roosevelt Stadium in Jersey City, N.J., Kennedy enters the game as a pinch-runner.

On April 22, 1978, "Saturday Night Live" showcases the worldwide television debut of the Blues Brothers—the not-quite-real, not-quite-fake musical creation of SNL cast members Dan Aykroyd and John Belushi.

Seven days after the death of Hu Yaobang, the deposed reform-minded leader of the Chinese Communist Party, some 100,000 students gather at Beijing’s Tiananmen Square to commemorate Hu and voice their discontent with China’s authoritative communist government. An official memorial service for Hu Yaobang was being held in Tiananmen’s Great Hall of the People, and student representatives carried a petition to the steps of the Great Hall, demanding to meet with Premier Li Peng. The Chinese government refused such a meeting, leading to a general boycott of Chinese universities across the country and widespread calls for democratic reforms.

On April 22, 1994, former President Richard M. Nixon dies after suffering a stroke four days earlier. In a 1978 speech at Oxford University, Nixon admitted he had screwed up during his presidency but predicted that his achievements would be viewed more favorably with time. He told the young audience, “You’ll be here in the year 2000, see how I am regarded then.”

Pat Tillman, who gave up his pro football career to enlist in the U.S. Army after the terrorist attacks of September 11, is killed by friendly fire while serving in Afghanistan on April 22, 2004. The news that Tillman, age 27, was mistakenly gunned down by his fellow Rangers, rather than enemy forces, was initially covered up by the U.S. military.