As Dr. Katherine Hall, a senior lecturer at the Dunedin School of Medicine at the University of Otago, New Zealand, wrote in a 2018 article published in The Ancient History Bulletin, most other theories of what killed Alexander have focused on the agonizing fever and abdominal pain he suffered in the days before he died.
In fact, she points out, he was also known to have developed a “progressive, symmetrical, ascending paralysis” during his illness. And though he was very sick, he remained compos mentis (fully in control of his mental faculties) until just before his death.
Hall argues that GBS, a rare but serious autoimmune disorder in which the immune system attacks healthy cells in the nervous system, can explain this combination of symptoms better than the other theories advanced for Alexander’s death. She believes he may have contracted the disorder from an infection of Campylobacter pylori, a common bacterium at the time. According to Hall, Alexander likely got a variant of GBS that produced paralysis without causing confusion or unconsciousness.
Challenging the Timing of Alexander's Death